Translational Autoimmunity, Volume 3

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To fulfil its mission as an in-detail translational step to tackle autoimmunity, Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses sufficiently basic questions on how the immune system is designed to distinguish self from no self and behave such that able to maintain self-tolerance, how does it work when as in infections, a malfunction that impedes its normal processes occurs, and how it will elicit an auto-reactive state and results in recognition of self-antigens as seen in autoimmune conditions. It is followed by an overview on the genetic and clinical aspects of the spectrum of autoimmune diseases which are broadly categorized into two types of organ specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses autoimmunity and associated conditions, such as aging, infectious diseases, cancer, neurodegeneration, psychological disorders, fertility, inflammatory vascular diseases, and interstitial lung diseases. Immunodeficiencies association with autoimmunity, either primary like severe combined immunodeficiencies or secondary like HIV infection are also discussed in the third volume of "Translational Immunology¿ Book Series. The immunological mechanisms of autoimmunity are unraveled by looking at the other conditions associated with autoimmune manifestations in Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings.