The Benefit/Risk Ratio

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The use of drugs as remedies for various types of diseases has a long tradition. However, it has only been recently recognized that the value of any given compound must be evaluated in light of its benefit to risk ratio. When prescribing drugs, physicians must look at the big picture of the drug's benefits in relation to its side effects and possible toxicity. The aim of this handbook is to compile data from various authors, providing clinicians with data that will optimize their decision making in selecting effective, low-risk drug treatments. TOC:The Role and Analysis of Benefit and Risk in the Development of New Drugs.- Prediction of the Benefit/Risk Ratio from In Vitro Data.- Evaluation of Therapeutic Benefits and Toxicological Risks Using Structure-Activity Relational Expert Systems.- Improving the Therapeutic Index Through Unusual Routes of Application.- Establishing the Benefit/Risk Ratio with Combination Drugs.- Improving the Therapeutic Index of Antineoplastic Agents through Additional Drugs.- Antihypertensive Agents.- Diuretics.- Anti-Diabetic Drugs.- Anticonvulsant Drugs and Drugs for Parkinsons Disease.- Antihistamines and Antiserotonins.- Cytokines and Immunomodulators.- Non-Opioid Analgesics and Anti-Inflammatory Agents.- Toxicity Profile of Liposomal Anthracyclines.- Index.