The AH Receptor in Biology and Toxicology

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The complete guide to the aryl hydrocarbon receptor (AHR)-what it is, what it does, and what it might mean for the future of drug metabolism Providing a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the induction of drug-metabolizing enzymes and diverse toxicities caused by dioxins, The AH Receptor in Biology and Toxicology is essential reading for toxicologists, chemists, biologists, pharmacologists, and other experts studying drug metabolism. Evidence suggests that the AHR protein imparts important physiological functions that place it at the crossroad of biology and toxicology, making it the focus of extensive research activity. Examining the unique dual role of AHR as both a toxicant and a factor in biological processes, this comprehensive reference work covers the full spectrum of AHR topics from basic concepts, toxicological risk analysis, and models, to polymorphisms and related diseases. Addressing epigenetic mechanisms, gene expression, reproductive/developmental toxicity, signal transduction, and transgenic animal models, the book runs the gamut of AHR knowledge. With contributions from renowned international experts, The AH Receptor in Biology and Toxicology puts the forefront of AHR research at your fingertips.