Structural characterisation of NSAIDS and cyclodextrin-NSAID complexes

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Non- steroidal anti-inflammatory drugs (NSAIDs) are used for the prevention of pain and inflammation. Since, however, the solubility and bioavailability of NSAIDs are generally poor, encapsulation of these drugs in cyclodextrins was attempted in order to alter their dissolution properties. Under different thermodynamic and kinetic conditions a chemical substance may crystallise into different crystalline forms (polymorphs). These different species, due to their different crystal structures have different physical properties such as solubility and dissolution rate and therefore the most appropriate polymorph needs to be identified for optimum bioavailability. In the work reported here several NSAIDs, were studied for possible inclusion or novel crystalline phase isolation. In addition, some insight is provided as to why the popular NSAID, Vioxx®, was pulled off the shelves.