Smart Nanomaterials Targeting Pathological Hypoxia

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The present medical sciences identify pathological hypoxia as etiological as well as causative in a wide range of diseases such as cancers and tumors, cardiovascular distress, high altitude diseases, pulmonary fibrosis, and pulmonary viral infections. Moreover, this component of hypoxia creates a molecular milieu which adds to robustness of the disease phenotype, limiting the efficacy of therapeutic interventions and at the same time triggering a cascade of pro-oxidant, pro-inflammatory mediators further exaggerating the disease. It has been noticed that the smart nanomaterials have revolutionized diagnostics, imaging, drug delivery, and therapeutic formulations with enhanced efficacy in disease management. This book showcases the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings, by various experts in the field. Overall, the themes in the book touch upon critical facets to address pathological hypoxia-nanomaterials enhancing oxygenation, hypoxia responsive nano-formulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nano-formulations to counter molecular consequences of hypoxia, theranostic combining hypoxia detection systems with drug delivery systems, etc. The book covers a wide range of concepts and new age advancements in the field of "intelligent" nanomaterials relevant to health care and is widely useful for the students, researchers, industry experts, and academia.