Scientific Memoirs by Officers of the Medical and Sanitary Departments of the Government of India

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Excerpt from Scientific Memoirs by Officers of the Medical and Sanitary Departments of the Government of India: Snake-Venoms in Relation to HaemolysisIn following up the results got with cobra venom and the washed cells of class A they show by a series of ingenious experiments that the reason why these cells, even when carefully and thoroughly washed, are sensitive to cobra venom alone, is that the lecithin contained within them is able to act as an activating substance. They prove that the lecithin is bound to the stroma of the cells, and that on dissolving rezi cells with distilled water it remains attached to the stroma they offer as a probable explanation of the non-sensitiveness of the cells of class B to cobra venom the supposition that the lecithin contained in these cells is so firmly bound to the stroma that the venom cannot separate it from this binding. Kyes and Sachs in further elaborating these discoveries show that free lecithin prepared from the yolk of egg can act as complement for cobra venom and the cells which are not dissolved by the venom alone, they carefully compare the action of lecithin with that of serum complement and, while they show that there are several important differences in the conditions of working of these two substances, they are of opinion that the action of lecithin is of the same nature as that of serum complement. They also point out that Calmette's observation', namely, that certain normal sera are more suitable to cause haemo lysis with cobra venom after they have been heated than in the fresh condition, receives a simple explanation in the light of their observations. They show, in fact, that this thermostabile substance in serum which acts as a complement to cobra venom is nothing more or less than lecithin. Which probably by the heating of the serum becomes loosened or entirely freed from its bindings, and which only then is ina condition to be taken up by the amboceptor of the poison.About the PublisherForgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.comThis book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully, any imperfections that remain are intentionally left to preserve the state of such historical works.