Randomised Controlled Clinical Trials

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After 13 years there are new areas to discuss and more recent trials to be included. Good clinical practice, evaluation of quality of life, measurement of the benefit:risk comparison, determination of cost- effectiveness and cost utility, stopping rules for trials, meta-analysis and subgroup analysis are all new sections. The references are expanded from 305 to 512 and include the recent advances in trial design, such as the n-of-1 trials and megatrials, and up-to-date examples to illustrate the points made in the 20 chapters.