The Pten Family

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Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of PTEN biology and its roles in human diseases. The contributors discuss the structural characteristics of PTEN, its functions at the plasma membrane as well as in the cytoplasm and nucleus, the mutations, interacting partners, and posttranslational modifications that affect its expression levels, subcellular localization, and enzymatic activity, and how this activity ultimately leads to changes in cell growth, migration, and morphology, as well as in gene expression, chromatin dynamics, and the maintenance of genomic stability. A historical perspective that covers the initial discovery and subsequent characterization of PTEN is also included.