Protein Misfolding, Aggregation and Disease

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This book encompasses topics from the fundamentals of disease related protein misfolding and mass spectrometry, to current research highlights in these areas. It is aimed to provide an overview of this rapidly developing field in order to present a good mixture of information that will encourage people to participate in, and further the use of mass spectrometry in studying protein misfolding with biologically relevant applications. Using examples from the current literature, the book focuses on details relating to understanding the fundamentals of disease related protein misfolding, conducting and optimising the mass spectrometry experiment, and also future prospects of methodologies within this rapidly evolving and topical research area. Using current examples and high-quality illustrations, this book covers topics including how to conduct and optimize experiments, the structural and atomic level information afforded by mass spectrometry in disease related protein systems, and incorporates future research prospects.