Protein Binding of Angiotensin Receptor II Antagonist

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This book is related to a study where binding of Losartan Potassium and Valsartan, two anti-hypertensive drugs to Bovine Serum Albumin (BSA)were studied by Equilibrium Dialysis Method.The binding of Losartan Potassium and Valsartan was characterized by two sets of Association Constants.Losartan Potassium showed slightly higher affinity towards BSA than Valsartan.Different analyses of binding to BSA suggested the presence of one high affinity site and four to five low affinity sites for Losartan Potassium and Valsartan.Site-specific probe displacement data implied that both Losartan Potassium and Valsartan primarily bind to site I, the warfarin site, while the low affinity site of these two drugs was site II, the Benzodiazepine site on BSA.During concurrent administration of Losartan potassium and Valsartan, both drugs have been found to increase the respective free concentration of one another causing reduced binding to BSA.This book will be helpful for the students and researchers of Pharmacy discipline specially those who are interested or engaged in research related to Protein Binding.