Precision Medicine in Neurodegenerative Disorders

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Precision Medicine in Neurodegenerative Disorders, Part One, Volume 193 discusses a major transformation fueled by the recognition that what has worked for developing symptomatic therapies doesn't necessarily work for developing disease modifying therapies. The former depends on addressing convergent, common denominators of disease, present in most of those affected. The latter on divergent biological signals, present in some but absent in most. This work encompasses two volumes separated into multiple sections, including conceptual frameworks, pitfalls in definitions, cohorts, and measures of progression, basic science development, and clinical trials and therapeutic approaches.