Physiology and Pathophysiology of the Heart

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could go on for several pages. Thus the book edited This book emphasizes the fundamental, functional aspects of cardiology. Within the last thirty years, by Sperelakis IS a potent reminder of the almost for­ the rift between clinical and investigative cardiology gotten fact that cardiology has twO sites, inextrica­ has widened, because of the overwhelming devel­ bly related. opment of new clinical procedures, both diagnostic The book deals with subjects in which Dr. Sper­ and therapeutic. Almost forgotten is the fact that elakis has pioneered: ultrastructure of heart muscle, we owe most of the clinical advances to theoretical electrophysiology, cardiac contractility, and ion ex­ and experimental observations. I need not remind change. An extension of these subjects is the chapter the reader of the work of Carrel, who performed the dealing with fundamental topics of the coronary cir­ first experimental coronary bypass in 1902, or the culation. work of the brothers Curie in 1880, both physicists, This book is indeed a timely reminder of the im­ who discovered piezoelectricity, the keystone in ech­ portance of the fundamental aspects of cardiology. ogradiography, of the works of Langley, who intro­ Emphasis on clinical aspects of cardiology alone will duced the receptors concept, of Ahlquist in 1946, result in a sterile and unproductive future for a field who first differentiated between alpha and beta re­ that has made such stunning advances during the ceptors, of Fleckenstein, a physiologist who pi­ last thirty years to the benefit of millions of people.