p53 ji huo ji RITA ji qi lei si wu de she ji he cheng ji qi kang zhong liu yan jiu

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RITA zai xu duo han ye sheng xing p53 de zhong liu xi bao zhong neng gou gan rao p53 MDM2 de xiang hu zuo yong zhong xin ji huo p53 jin er zu zhi zhong liu xi bao zhou qi you dao zhong liu xi bao diao wang er ben shu zheng fa zhan le yi zhong he cheng RITA ji qi lei si wu de xin fang fa bing chan shu le zhe xie hua he wu xin de kang zeng zhi ji zhi shou xian ben shu yi RITA zuo wei xian dao hua he wu tan suo le he cheng RITA ji qi lei si wu de xin fang fa tong guo shi yong lian jia yi de de yuan liao yi Suzuki fan ying gou jian C C jian zai shi wen tiao jian xia shi yong qie gao shou lv di he cheng le RITA ji qi lei si wu er ci fang fa bian yu shi xian RITA de gong ye hua jie guo yan jiu fa xian 100 nM de RITA he hua he wu 1f zai HCT116 zhong ke yi ming xian di ji huo p53 de biao da zai HCT116 xi bao RITA ji qi hua he wu 1f 400 nM tong guo shang diao miR 34a de biao da xia diao qi xia you ba dan bai E2F1 CDK4 de biao da you dao zhong liu xi bao zhou qi zu zhi yu G0 G1 he zhong liu xi bao diao wang tong shi ben shu huan fa zhan le yi zhong wen he qie fei guo du jin shu cui hua wo yu er fang ji dian weng yan de fang ji hua fan ying de fang fa zai yan suan deng cui hua xia jian ji he cheng le tian ran chan wu Stemofuran A he Coumestan bian yu zhi bei RITA lei si wu