New Drug Discovery and Development

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A case history approach to drug synthesis and discovery Discover the origins of some of the most popular drug therapies on the market today, including penicillin, Minoxidil, Viagra(r), and "the pill." This guide to drug synthesis and discovery focuses on case histories. Organized by drug category, the guide introduces readers to the rich interplay of research and serendipity that is responsible for many commonly prescribed drugs today. Moreover, the author demonstrates how the discovery and development of a new drug or drug category creates a domino effect, leading to the development of newer therapeutics as pharmaceutical companies compete to satisfy market demands. Readers gain new insight from both a chemical and medical perspective into: * Major classes of antibiotics used to treat infectious diseases * Antiviral drugs, including recent antiviral compounds designed to take advantage of new findings concerning the molecular biology of viral infection * Growth of several classes of analgesics * Intricate chemical structure of steroids * Development of compounds designed to lower cholesterol * Discovery of COX-2 nonsteroidal anti-inflammatory drugs (NSAIDs) * Research and development of oral contraceptives The text ends with an overview of the many steps required before a drug may be approved by the U. S. Food and Drug Administration. Lavishly illustrated with chemical structures, and supplemented by an appendix for those readers who need assistance in interpreting the structures, the text is highly suited for students in medicinal chemistry, as well as for researchers in pharmaceuticals and medical practitioners in search of new insights into drug synthesis and discovery.