Methods in Microarray Normalization

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Molecular profiling microarrays show what genes are present in a particular cell type, at a particular time, under particular conditions. Etched onto a microchip, these "profiles" allow researchers to compare healthy cells with their diseased counterparts and develop gene-specific treatments. This book describes all types of normalization techniques for expression data and their impact on a variety of molecular profiling technologies for both clinical and research applications. Many of the techniques are so new, this is the first publication to compile and analyze them in a single source. Topics include new normalization methods for protein, SNP, and CGH arrays, many of which are applicable for antibody, microRNA, methylation, and siRNA arrays. Several examples of these methods either currently exist or are forthcoming as part of commercial software products, but many are freeware.