Medical Applications of Finite Mixture Models

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The book shows how to model heterogeneity in medical research with covariate adjusted finite mixture models. The areas of application include epidemiology, gene expression data, disease mapping, meta-analysis, neurophysiology and pharmacology. After an informal introduction the book provides and summarizes the mathematical background necessary to understand the algorithms. The emphasis of the book is on a variety of medical applications such as gene expression data, meta-analysis and population pharmacokinetics. These applications are discussed in detail using real data from the medical literature. The book offers an R package which enables the reader to use the methods for his/her needs.