Lifetime Exposure to Arsenic in Drinking Water

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Revision with unchanged content. Ingestion of arsenic in drinking water has been linked with the risk of bladder cancer, however, questions remain about the dose-response relationships, ranges in induction-latency intervals, and whether there are critical lifetime exposure periods of heightened susceptibility. This book describes how indivi­dual-level estimates of arsenic exposure are reconstructed using newly developed Space-Time Information System technology, and offers methodo­logical approaches for evaluating temporal dynamics in the relationship between arsenic exposure and bladder cancer. Spatial, temporal, and spatio-temporal variability are incorporated in the assessment of lifetime exposure to arsenic. Fluid and food consumption data are joined with mobility histories and arsenic concentrations to generate a detailed lifetime asses­sment of arsenic exposure. These exposure estimates will be used in a population-based bladder cancer case-control study nearing completion in southeastern Michigan. This work is directed to exposure scientists, environ­mental epidemiologists, health geographers, GIScientists, and others interested in the links between environment, human health, and spatial tech­nology.