Introduction to Strategies for Organic Synthesis

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BRIDGING THE GAP BETWEEN ORGANIC CHEMISTRY FUNDAMENTALS AND ADVANCED SYNTHESIS PROBLEMS Introduction to Strategies for Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist's point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule. Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule. This new Second Edition of Introduction to Strategies for Organic Synthesis: * Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms * Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions * Helps students envision forward reactions and backwards disconnections as a matter of routine * Gives students confidence in performing retrosynthetic analyses of target molecules * Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions * Provides clear explanations in easy-to-follow, student-friendly language * Focuses on the strategies of organic synthesis rather than a catalog of reactions and modern reagents The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.