Interferons

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Interferons are cytokines that are very important in regulating both innate and adaptive immune response. Of the two different types of interferons, Type I interferons are potent mediators of the innate immune response against viruses and cancer. Type II interferons, mainly IFN-y enhances T cell polarisation in the lymph nodes that result in their expansion. This book discusses the characterisation, mechanisms of action and clinical applications of interferons. Topics include interferon-gamma, oligodendrocyte injury and inflammatory demyelination, the role of IFN-y in oesophageal squamous cell carcinoma, interferons in multiple sclerosis, the effect of interferons on NK cell activity in HIV infection and tumour cell development, and understanding the mechanisms of interaction between serine proteases, serine protease receptors and interferons.