Gene Therapy Immunology

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The first comprehensive reviewof the immunologyof gene transfer Gene Therapy Immunology is the first book of its kind to summarize and present a broad review of the latest immunological advances in the field of genetic therapy. The book's unique organization, which approaches the topic from a vector and target organ point of view, rather than from a disease-specific perspective, reflects the ways in which gene therapies are being investigated today. This provides scientists and physicians attempting to develop gene therapies with a powerful tool for comparing vectors and target organs side by side, making the right investigative and clinical choices, anticipating potential problems, modifying protocols, and obtaining a broader view of the issues. Each chapter covers local and systemic responses, strengths and characteristics of innate responses, strengths and characteristics of adaptive (i.e., T helper, cytotoxic T lymphocyte, and B cell/antibody) responses to the vector and to transgene products, and preexisting immunity in humans. Authored by internationally renowned researchers and clinicians and edited by the former chair of the Immunology Committee of the American Society for Gene Therapy, this book is an indispensable resource for scientists, physicians, and students who work in gene therapy. It is also a valuable text for advanced undergraduate and graduate courses on immunology.