Immunolocalization and Evaluation of Thioredoxin Glutathione Reductase Role in Diagnosis of Human Schistosomiasis

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Doctoral Thesis / Dissertation from the year 2003 in the subject Biology - Parasitology, grade: PhD, Cairo University (Faculty of Science.), course: Immunoparasitology, language: English, abstract: Schistosoma parasite continued to be focus of the solicitude investigators to control the prevalence of the parasite. The efforts are needed for sensitive and accurate diagnosis that can utilize to rapidly map the prevalence of the disease. Our study aimed to benefit from the necessity of the S. mansoni for enzyme TGR, in utilization of the enzyme as an antigen target and evaluate its efficacy in the diagnosis of S. mansoni infection patients. The results revealed that smTGR could be detected in various organs of infected mice and localized in all parasites life cycle stages except eggs using smTGR pAb. Sandwich ELISA reveled that this antigen can be relied as a diagnostic antigen target in serum and urine.