HIV-1 Integrase

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Provides the Foundation Needed to Design Effective HIV-1 Integrase Inhibitors Around the world, scientists have been working for years with the goal of designing effective HIV-1 integrase inhibitors in the battle against AIDS. This book reviews all their latest research findings on both inhibitor design and the mechanisms of action of HIV-1 integrase. Chapters have been contributed by leading pioneers in the field from North America, Europe, and Asia. These contributions represent not only a thorough review of the current literature, but also the authors' firsthand experience in drug development and design. Coverage includes such topics as: * Integrase mechanism, structure, and function * HIV-1 integrase-DNA interaction * Host factors affecting provirus stability and silencing * Role of metals in HIV-1 integrase inhibitor design * Historic perspectives, challenges, and future opportunities As the first publication to comprehensively examine HIV-1 integrase, this book is essential reading for anyone involved in inhibitor drug discovery. * Integrates chemical, biochemical, and biological approaches, enabling readers to take full advantage of a promising target enzyme for combating HIV and retroviruses * Illustrates rational drug design for a complex drug target with plenty of step-by-step examples * Addresses drug design issues from a variety of perspectives to help readers understand both the challenges and opportunities of developing a successful HIV-1 integrase inhibitor This book fills an important gap in the review literature, offering a valuable introduction to the field for scientists who need to collaborate with researchers in several disciplines in order to design drugs that effectively target HIV-1 integrase.