Evidence for the existence of central monoamine neurons

Bücher

Angebote / Angebote:

It is important to remember how immature thecatecholamine field was in the beginning of the 1960 ies. At theCIBA Foundation Symposium on Adrenergic Mechanisms (London) in 1960Prof. Gaddum stated: "The meeting was in a critical moodand no one ventured to speculate on the relation betweencatecholamines and the brain" . It was therefore a major breakthroughin the monoamine field when it became possible in the1960ies with the help of a highly sensitive and specific fluorescence method for the cellular demonstration of catecholamines and 5-hydroxytryptamine, the so called Falck-Hillarptechnique , to directly demonstrate nerve cell systems in the CNSstoring and forming dopamine, noradrenaline and 5-hydroxytryptamine, respectively. This book gives the early evidencefrom the work of Fuxe and Dahlström that formed Fuxe's thesis in 1965on the existence of central monoamine neurons. Thisfundamental work is of interest to preclinical and clinicalneuroscienists world-wide in view of its impact on understanding communicationin the brainand development of neuropsychiatric disease and itshigh relevance for neuropsychopharmacology and neuroendocrinology.