Epigenetic Targets in Drug Discovery

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The genes that make up our genome are not static entities but undergo a complex modification process that results in certain genes being switched on or off, depending on the state of the cell. This so-called epigenetic regulation is now known in enough detail to allow its specific interference via targeted drugs, strengthening the fight against such human diseases as cancer and neurodegeneration with an epigenetic component. Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including coverage of the first successful drug candidates available for these novel targets.