Efficacy and Mechanism of Typhonium flagelliforme in Leukemia

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The plant Typhonium flagelliforme is often used as traditional remedy for alternative cancer therapies, including leukemia by various ethnic populations in Malaysia. This book provides the information regarding the cell death mechanism induced by this plant on leukemia. Since apoptosis is considered one of the suitable modes of cancer therapy, the study was framed accordingly. Linoleic acid rich fraction obtained from the tubers of the plant could potentially inhibit the proliferation of leukemic cells through mitochondrial pathway and tuber extracts also repressed the spleen leukemic tumor growth in WEHI-3 leukemia murine model, all by eliciting apoptosis.