DNA Repair and Mutagenesis

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Featuring more than 10, 000 references and lavishly complemented by over 700 high-quality illustrations, DNA Repair and Mutagenesis, 2nd Edition, is a timely update to the original edition published in 1995. The addition of three new authors, including an expert in the field of structural biology, ensures a comprehensive review of the most current research in diverse subject areas. An ideal textbook for advanced undergraduate and graduate students, the book is also an essential resource for all scientists researching cellular responses to DNA damage. Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. As with the first edition, this new volume presents the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. The book consists of 30 chapters divided into five main parts, covering sources and consequences of DNA damage, correcting altered bases in DNA: DNA repair, DNA damage tolerance and mutagenesis, regulatory responses to DNA damage in eukaryotes, and disease states associated with defective biological responses to DNA damage. Basic principles are appropriately stressed, however, the book focuses on the significant progress to date and future research directions.