De Novo Peptide Design

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The therapeutic value of peptides was recognized in the first half of the twentieth century, and they are now one of the preferred therapeutic agents. With the advent of nanotechnology peptide based nano-assemblies such as peptide nanotubes offer a new future for environmentally-friendly nano devices. The use of peptides in medical science as hormones and therapeutics is now well-established, and new therapeutic technologies continue to emerge. De novo Peptide Design presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focusses on the design of peptides, particularly how peptides may be tailored to specific functions. The book includes computational and experimental protocols to assist in the design of peptides. This title consists in 12 chapters, covering the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry. The volume covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents.