Chemical Approaches to the Synthesis of Peptides and Proteins

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The latest, most efficient methods for the synthesis of peptides and proteins. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides. TOC:Introduction. Amino Acids and Peptide and Protein Structure. Amino Acid Activation and Coupling. Protection Schemes for Peptide Synthesis. The Synthesis of Peptides. Solid- Phase Peptide Synthesis. The Solid Support. Protection Schemes. Attachment of the First Amino Acid to the Solid Support. Chain Elongation. Cleavage of the Peptide from the Resin. Examples of Protein Synthesis by Linear SPPS. Peptide Synthesis in Solution. Strategic Considerations. Protection Schemes. Chain Elongation. Final Removal of Protecting Groups and more.