Bone repair by stem cells

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Human multipotent stromal cells were first characterized by Alexander Friedenstein as fibroblastic colony-forming cells from the nonhematopoietic, culture vessel-adherent fraction of bone marrow. Bone marrow transplants had provided circumstantial evidence for the presence of precursor cells of the various components of bone marrow stroma: osteoblasts, adipocytes, chondrocytes, among others, while in vitro culture and differentiation of these colony-forming units provided more direct evidence of their existence.