Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

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Volume 95 of "International Review of Neurobiology" focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use. Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors Preclinical models in COMT inhibitor devlopment Transgenic COMT mice latest information summarized Chemistry of COMT inhibitors and their design with molecular modelling COMT gene and its regulation and relation to dopamine related diseases Role of cofactor SAM regulation in relation to homocysteine Nonclinical and clinical safety of COMT inhibitors summarized Future prospects of COMT inhibitors in Parkinson s disease