Annual Reprint of the Reports of the Council on Pharmacy and Chemistry

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Excerpt from Annual Reprint of the Reports of the Council on Pharmacy and Chemistry: Of the American Medical Association for 1921 The Council has authorized publication of the following report. W. A. Puckner, Secretary. For nearly forty years, agaric acid or related preparations have been recommended for the control of night sweats in tuberculosis. There has, therefore, been ample opportunity to test this relatively simple action and to compare the effectiveness of agaric acid with other measures used for this purpose. A review of some of the standard textbooks on therapeutics and on tuberculosis shows that agaric acid has not proved to be a useful drug for this purpose. In a number of books, it is said that it is effective but that it must often be combined with opium on account of a tendency to produce diarrhea. It is too irritating to be used in subcutaneous injections. In these respects, it is inferior to atropin, and the latter seems equally, or more, effective in controlling the sweating. Hare states that in his experience agaric acid does not control the night sweats. The drug is not mentioned in the discussions on the treatment of night sweats written by L. Brown (Osler's System of Medicine), by Krause (Nelson's Loose Leaf System), and by H. M. King (Forchheimer's Therapeusis). Examination of the Index Medicus for the years 1910-1919, inclusive, shows only one article indexed under this title. This was an experimental study by Fred Ransom, in which the pharmacologic evidence was rather against agaric acid's being analogous to atropin in its action. In consideration of the preceding, the Council voted to omit agaric acid from New and Nonofficial Remedies. As a matter of record, the description of agaric acid which appears in New and Nonofficial Remedies, 1921, was referred to the Council Reports and follows herewith: Agaric Acid. - Acidum Agaricum. - Acidum Agaricinicum. - Agaricinum. - A tribasic acid, C19H36OH (COOH)3 + 1¿ H2O, derived from Polyporus officinalis, Fries (Order Hymenomycetes, fam. Polyporeae) a fungus growing on the European larch and other species of larch. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully, any imperfections that remain are intentionally left to preserve the state of such historical works.