Adaptive and Flexible Clinical Trials

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By enabling studies to be modified during the course of the trial, modern adaptive clinical trial designs can make studies substantially faster, more efficient, and more powerful than traditional clinical trials. The recent advances in web-based real-time data entry and novel statistical methods have made adaptive clinical trials practical and attractive. Suitable for readers involved in drug development, this is the first book that comprehensively explains all essential aspects of adaptive clinical trials. Without using highly technical statistical jargon, it discusses the design, conduct, and execution of these trials.